Chromatin dynamics and epigenetic regulation of gene expression, Cell Fate Determination, Cell Differentiation
Cancer epigenetics, Epigenetic mechanism of tumorigenesis
Molecular mechanism-based drug development
Molecular understanding of tumor suppressor function & cancer biology
Noncoding RNAs, Transcriptome analysis
학력
(Ph.D.) 1990-1996, 서울대학교 대학원 미생물학과 분자생물학 전공 (박사)
(MS) 1988-1990, 서울대학교 대학원 미생물학과 분자생물학 전공 (석사)
(BS) 1984-1988, 서울대학교 자연과학대학 미생물학과 (학사)
약력/경력
2011-현재, 성균관대학교 약학대학 교수
2001-2011, 성균관대학교 약학대학 조교수, 부교수
1996-2001, Harvard Medical School, 박사후 연구원
학술지 논문
(2023)
Determination of HIF-1α degradation pathways via modulation of the propionyl mark.
BMB REPORTS.
56,
4
(2022)
Menin Enhances Androgen Receptor-Independent Proliferation and Migration of Prostate Cancer Cells.
MOLECULES AND CELLS.
45,
4
(2021)
Phosphorylation of OGFOD1 by Cell Cycle-Dependent Kinase 7/9 Enhances the Transcriptional Activity of RNA Polymerase II in Breast Cancer Cells.
CANCERS.
13,
14
(2020)
Histone acylation marks respond to metabolic perturbations and enable cellular adaptation.
EXPERIMENTAL AND MOLECULAR MEDICINE.
52,
12
(2018)
Long non-coding RNA ChRO1 facilitates ATRX/DAXX-dependent H3.3 deposition for transcription-associated heterochromatin reorganization.
NUCLEIC ACIDS RESEARCH.
46,
22
(2018)
Abundance of C-terminal binding protein isoform is a prerequisite for exit from pluripotency in mouse embryonic stem cells.
FASEB JOURNAL.
32,
12
(2018)
Zinc finger proteins orchestrate active gene silencing during embryonic stem cell differentiation.
NUCLEIC ACIDS RESEARCH.
46,
13
(2018)
Cyclin-dependent kinase 1 activity coordinates the chromatin associated state of Oct4 during cell cycle in embryonic stem cells.
NUCLEIC ACIDS RESEARCH.
46,
13
(2017)
Ctbp2-mediated beta-catenin regulation is required for exit from pluripotency.
EXPERIMENTAL AND MOLECULAR MEDICINE.
49,
10
(2017)
Direct interaction of menin leads to ubiquitin-proteasomal degradation of beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.
492,
1
(2016)
Psat1-Dependent Fluctuations in alpha-Ketoglutarate Affect the Timing of ESC Differentiation.
CELL METABOLISM.
24,
3
(2016)
Differential regulation of the histone chaperone HIRA during muscle cell differentiation by a phosphorylation switch.
EXPERIMENTAL AND MOLECULAR MEDICINE.
48,
(2016)
Aurkb/PP1 mediated resetting of Oct4 during the cell cycle determines the identity of embryonic stem cells.
ELIFE.
5,
(2015)
Identification of small molecules that inhibit the histone chaperone Asf1 and its chromatin function.
BMB REPORTS.
48,
12
(2015)
Transcriptional repression of cancer stem cell marker CD133 by tumor suppressor p53..
CELL DEATH & DISEASE.
6,
1
(2015)
Core Pluripotency Factors Directly Regulate Metabolism in Embryonic Stem Cell to Maintain Pluripotency.
STEM CELLS.
33,
9
(2015)
AKT phosphorylates H3-threonine 45 to facilitate termination of gene transcription in response to DNA damage.
NUCLEIC ACIDS RESEARCH.
43,
9
(2015)
Ctbp2 Modulates NuRD-Mediated Deacetylation of H3K27 and Facilitates PRC2-Mediated H3K27me3 in Active Embryonic Stem Cell Genes During Exit from Pluripotency.
STEM CELLS.
33,
8
(2015)
OGFOD1 is required for breast cancer cell proliferation and is associated with poor prognosis in breast cancer.
ONCOTARGET.
6,
23
(2014)
ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway.
FEBS Journal.
282,
2
단행본
(2009)
약품생화학총정리.
동명사.
공동
(2005)
약품생화학총정리(개정판).
동명사.
공동
(2004)
약품생화학총정리.
동명사.
공동
(2003)
분자약품 생화학 약품생화학분과위원회 편, 동명사 2003.
동명사.
공동
특허/프로그램
근조직 재생 기능과 근위축 진단 마커 역할의 ChRO1 RNA.
10-2018-0106439.
20200109.
대한민국
근조직 재생 기능과 근위축 진단 마커 역할의 ChRO1 RNA.
10-2018-0106439.
20200109.
대한민국
학술회의논문
(2020)
Role of p300-mediated modification of Hypoxia-inducible factor (HIF)-1α in the regulation of HIF-1α stability and function.
2020 International Conference: Korean Society for Molecular and Cellular Biology, Online symposium.
대한민국
(2020)
Analysis of Menin in breast cancers reveals its role in cancer epigenome regulation.
Korean Society for Molecular and Cellular Biology, Online symposium 2020.
대한민국
(2020)
Implication of menin in chromatin dysfunction involving PML-DAXX/ATRX-H3.3 axis.
Korean Society for Molecular and Cellular Biology, Online symposium.
대한민국
(2019)
Analysis of Menin in breast cancers reveals its role in cancer epigenome regulation.
2019 Asia Conference of Transcription.
뉴질랜드
(2019)
Pericentromeric heterochromatin clustering is impaired in muscle atrophy.
2019 Asia Conference of Transcription.
뉴질랜드
(2019)
Role of p300-mediated modification of Hypoxia-inducible Factor (HIF)-1α in the regulation of HIF-1α stability and function.
2019 Asia Conference of Transcription.
뉴질랜드
(2019)
Metabolic state of C2C12 skeletal muscle affects nuclear H3K23 acylations..
Abcam Epigenetics Conference and 14th Asia Epigenome Meeting (AEM).
대만
(2019)
Novel long noncoding RNAs involved in nuclear reorganization and myogenic cell differentiation.
2019 KSMCB 리보핵산분과 심포지움.
대한민국
(2018)
Heterochromatin reorganization and myogenic gene regulation.
2018 KSMCB 에피유전체학분과 심포지움.
대한민국
(2018)
Functional analysis of menin and SUV39H1 in prostate cancer.
2018 에피유전체학분과 심포지움.
대한민국
(2018)
Long noncoding RNA ChRO1 facilitates DAXX-dependent H3.3 deposition for heterochromatin reorganization in muscle differentiation.
MRC 연합성과발표회.
대한민국
(2018)
K709-propionylation of Hypoxia-induciblr Factor(HIF)-1α protects lysosomal degradation under hypoxia.
대한약학회 2018 추계 국제학술대회.
대한민국
(2018)
Long noncoding RNA ChRO1 facillitates heterochromatin reorganization in muscle differentiation.
대한약학회 추계 국제학술대회.
대한민국
(2018)
Understanding of menin as a scaffold protein for gene regulation.
대한약학회 2018 추계 국제학술대회.
대한민국
(2017)
Metabolic state of skeletal muscle affects nuclear histone acylations.
KSMCB 에피유전체학분과심포지움.
대한민국
(2017)
Metabolic state of skeletal muscle affects nuclear histone acylations.
KSMCB 에피유전체학분과심포지움.
대한민국
(2017)
Menin Tumor Suppressor has an Oncogenic Function in Prosatate Cancer.
Internatioonal conference Korean Society for Molecular and Cellular Biology.
대한민국
(2017)
Role of p300-mediated modification of Hypoxia-unducible Factor (HIF)-1α in the regulation of HIF-1α stability and function.
Internatioonal conference Korean Society for Molecular and Cellular Biology.
대한민국
(2017)
Study of the chromatin changes associated with skeletal muscle atrophy.
Internatioonal conference Korean Society for Molecular and Cellular Biology.
대한민국
(2017)
Identification and Characterization of a Novel Long non-coding RNA in myogenesis.
Asian Conference on Transcription-XV.
말레이시아
